Which group of patients might experience increased sedation from antiemetics?

The group of patients that might experience increased sedation from antiemetics is often the elderly and those with respiratory conditions.

Elderly patients frequently have increased sensitivity to medications due to factors such as altered pharmacokinetics and pharmacodynamics, as well as the possibility of polypharmacy, which can enhance the sedative effects of antiemetics. This age group is more likely to experience side effects such as sedation because their bodies process drugs differently, often resulting in a longer duration of action or higher plasma levels of the medication.

Patients with respiratory conditions might also possess increased sensitivity to sedative effects because some antiemetics, particularly those that are centrally acting (like certain antihistamines), can depress the central nervous system. This could potentially exacerbate their respiratory issues, leading to more significant sedative effects. Thus, both elderly patients and those with respiratory problems are at a higher risk of experiencing sedation when taking antiemetics.