Which antiemetic is considered safe for use in pregnancy?

Dimenhydrinate is often regarded as a safe option for use in pregnancy due to its historical use and established safety profile in treating nausea and vomiting. It is an antihistamine that has been commonly prescribed for motion sickness and is frequently employed in pregnancy-related nausea, particularly in the first trimester. Clinical studies and guidelines support its use during pregnancy, suggesting that the benefits of managing nausea often outweigh potential risks.

In contrast, while other antiemetics like ondansetron have some evidence of safety, particularly in specific populations, they must be used with caution and after careful consideration of risks and benefits. Dronabinol, a cannabinoid derivative, is not typically first-line due to potential effects on fetal development. Promethazine, though used in some cases, may pose risks of sedation and extrapyramidal symptoms in neonates if used late in pregnancy.

Dimenhydrinate’s long-standing use in pregnant populations, combined with its relatively favorable safety profile, solidifies its status as a trusted antiemetic during this time.