What metabolic effect can ondansetron cause in certain patients?

Ondansetron, a selective serotonin 5-HT3 receptor antagonist, is primarily used to prevent nausea and vomiting, especially in patients undergoing chemotherapy or surgery. One notable metabolic effect of ondansetron is the potential to cause a prolonged QT interval on an electrocardiogram (ECG).

Prolonged QT interval is significant because it indicates delayed repolarization of the heart, which can lead to life-threatening arrhythmias such as Torsades de Pointes. This side effect is particularly important in patients who may already be at risk for cardiac issues, including those with existing heart conditions, electrolyte imbalances, or those on other medications that can also prolong the QT interval.

Understanding this effect is crucial for healthcare professionals when considering ondansetron for patients, as careful monitoring may be necessary to ensure patient safety, especially in those with known risk factors for QT prolongation. Other options, while they may have their own clinical significance, do not directly relate to ondansetron's known metabolic effects as clearly as the potential for QT interval prolongation.