What liquid should a client prescribed aprepitant avoid?

A client prescribed aprepitant should avoid grapefruit juice because it can significantly affect the metabolism of the medication. Aprepitant is primarily metabolized by the cytochrome P450 3A4 enzyme system, and grapefruit juice is known to inhibit this enzyme. When grapefruit juice is consumed, it can lead to increased levels of aprepitant in the bloodstream, potentially enhancing its side effects or causing toxicity. Therefore, to ensure the medication is effective and to minimize adverse effects, it is important to avoid grapefruit juice while undergoing treatment with aprepitant. This consideration is particularly critical in ensuring the safety and efficacy of the drug therapy.