What is the mechanism of action of cannabinoid antiemetics?

Cannabinoid antiemetics utilize the body's endocannabinoid system to exert their effects. The mechanism of action involves stimulating cannabinoid receptors, particularly CB1 receptors, primarily located in the brain and gastrointestinal tract. By activating these receptors, cannabinoid antiemetics can reduce nausea and vomiting while simultaneously stimulating appetite.

The unique property of cannabinoids allows them to modulate neurotransmitter release, decreasing the signals that lead to nausea. This mechanism is particularly beneficial in patients undergoing chemotherapy or suffering from conditions that cause significant nausea and vomiting. The interaction with the endocannabinoid system provides an alternative pathway for managing these symptoms, distinct from traditional antiemetics that primarily act on other receptors, such as serotonin or dopamine receptors. This is why stimulating appetite and reducing nausea through cannabinoid receptors is the correct understanding of the mechanism of action for cannabinoid antiemetics.